Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369296 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
In continuation of our program aimed at the discovery and development of natural-product-based insecticidal agents, a series of novel hydrazone derivatives of podophyllotoxin, which is a naturally occurring aryltetralin lignan and isolated as the main secondary metabolite from the roots and rhizomes of Podophyllum species, were synthesized and evaluated as insecticidal agents against the pre-third-instar larvae of oriental armyworm, Mythimna separata (Walker) in vivo at 1 mg/mL. Especially compounds 8i, 8j, 8t, and 8u showed the more potent insecticidal activity with the final mortality rates greater than 60%.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yi Wang, Xiang Yu, Xiaoyan Zhi, Xiao Xiao, Chun Yang, Hui Xu,