| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369300 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
A diverse library of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives were prepared for evaluation of activity against the nucleocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV, using an in vitro cell culture approach, yielding nanomolar active compounds with low toxicity.
Graphical abstractA diverse library of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives were prepared for evaluation of activity against the nucleocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV, using an in vitro cell culture approach, yielding nanomolar active compounds with low toxicity.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
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Organic Chemistry
![Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection](/preview/png/1369300.png "First Page Preview: Evaluation of the antiviral efficacy of bis[1,2]dithiolo[1,4]thiazines and bis[1,2]dithiolopyrrole derivatives against the nucelocapsid protein of the Feline Immunodeficiency Virus (FIV) as a model for HIV infection")
Authors
Christopher R.M. Asquith, Marina L. Meli, Lidia S. Konstantinova, Tuomo Laitinen, Mikael Peräkylä, Antti Poso, Oleg A. Rakitin, Karin Allenspach, Regina Hofmann-Lehmann, Stephen T. Hilton,