| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369307 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
The isoquinolinone-based tricyclic compounds were designed and synthesized. Preliminary biological study of these compounds provided potent compounds 17a, 33b, 33c, 33d, and 33g with low nanomolar IC50s against PARP-1 enzyme.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jianyang Chen, Haixia Peng, Jinxue He, Xiajuan Huan, Zehong Miao, Chunhao Yang,