| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369315 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
Abstract
Starting from screening hit, (4S,7R)-1,7,8,8-tetramethyl-2-phenyl-1,2,4,5,6,7-hexahydro-4,7-methano-indazol-3-one (7), we optimized the potency and pharmacokinetic properties. This led to the identification of compounds with good in vivo activity in a mouse pharmacodynamic model of inhibition of 11βHSD1.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Paul Gillespie, Sherrie Pietranico-Cole, Michael Myers, Joseph A. Bilotta, Karin Conde-Knape, Nader Fotouhi, Robert A. Goodnow Jr., Kevin R. Guertin, Matthew M. Hamilton, Nancy-Ellen Haynes, Baolian Liu, Lida Qi, Yonglin Ren, Nathan R. Scott,