| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369328 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
A series of 6-nitro-3-(m-tolylamino) benzo[d]isothiazole 1,1-dioxide analogues were synthesized and evaluated for their inhibition activity against 5-lipoxygenase (5-LOX) and microsomal prostaglandin E2 synthase (mPGES-1). These compounds can inhibit both enzymes with IC50 values ranging from 0.15 to 23.6 μM. One of the most potential compounds, 3g, inhibits 5-LOX and mPGES-1 with IC50 values of 0.6 μM, 2.1 μM, respectively.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
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Authors
Erchang Shang, Yiran Wu, Pei Liu, Ying Liu, Wei Zhu, Xiaobing Deng, Chong He, Shan He, Cong Li, Luhua Lai,