| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369330 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
Bioassay-guided fractionation of the fruit powder of graviola (Annona muricata) yielded three novel compounds: muricins J, K, and L. The compounds are all C35 Annonaceous acetogenins with a mono-tetrahydrofuran ring and four hydroxyls. Their structures were elucidated by spectral methods and chemical modification after isolation via chromatographic techniques and HPLC purification. These three acetogenins demonstrated an antiproliferative against human prostate cancer PC-3 cells.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Shi Sun, Jingchun Liu, Hoda Kadouh, Xiuxiu Sun, Kequan Zhou,