| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369339 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
The anti-HIV-1 activity of GUT-70, a natural product derived from the stem bark of Chlophyllum brasiliense, was evaluated. GUT-70 inhibited HIV-1 replication in both acutely and chronically infected cells through suppression of NF-κB. Our results strengthen the idea that NF-κB pathway is one of the potential targets to control HIV-1 replication and that GUT-70 could serve as a lead compound to develop novel therapeutic agents against HIV-1 infection.
Graphical abstractThe tricyclic coumarin, GUT-70 derived from Chlophyllum brasiliense has inhibitory effects against HIV-1 replication in acutely and chronically HIV-1-infected cells via inhibition of the NF-κB.Figure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Eriko Kudo, Manabu Taura, Kouki Matsuda, Masako Shimamoto, Ryusho Kariya, Hiroki Goto, Shinichiro Hattori, Shinya Kimura, Seiji Okada,