| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369351 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
A novel series of anti-malarials, based on a hydroxy-ethyl-amine scaffold, initially identified as peptidomimetic protease inhibitors is described. Combination of the hydroxy-ethyl-amine anti-malarial phramacophore with the known Mannich base pharmacophore of amodiaquine (57) resulted in promising in vivo active novel derivatives.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Claire-Lise Ciana, Romain Siegrist, Hamed Aissaoui, Léo Marx, Sophie Racine, Solange Meyer, Christoph Binkert, Ruben de Kanter, Christoph Fischli, Sergio Wittlin, Christoph Boss,