| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369363 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
Protein arginin deaminase 4 (PAD4) is a calcium dependent enzyme which catalyses the conversion of peptidyl-arginine into peptidyl-citrulline and is implicated in several diseases such as rheumatoid arthritis (RA) and cancer. Herein we report the discovery of novel small-molecule, non peptidic PAD4 inhibitors incorporating primary/secondary guanidine moieties.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Murat Bozdag, Tobias Dreker, Christophe Henry, Paolo Tosco, Maura Vallaro, Roberta Fruttero, Andrea Scozzafava, Fabrizio Carta, Claudiu T. Supuran,