| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369388 | Bioorganic & Medicinal Chemistry Letters | 2013 | 5 Pages |
Abstract
We report our attempts at improving the oral efficacy of low-nanomolar inhibitors of xanthine oxidase from isocytosine series through chemical modifications. Our lead compound had earlier shown good in vivo efficacy when administered intraperitoneally but not orally. Several modifications are reported here which achieved more than twofold improvement in exposure. A compound with significant improvement in oral efficacy was also obtained.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Komal Bajaj, Sandeep Burudkar, Pranay Shah, Ashish Keche, Usha Ghosh, Prashant Tannu, Smriti Khanna, Ankita Srivastava, Nitin J. Deshmukh, Amol Dixit, Yogesh Ahire, Anagha Damre, Kumar V.S. Nemmani, Asha Kulkarni-Almeida, Chandrika B-Rao, Rajiv Sharma,