| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369393 | Bioorganic & Medicinal Chemistry Letters | 2013 | 4 Pages |
Abstract
A new actinomycete metabolite designated nosokophic acid was isolated from the culture broth of nosokomycin-producing Streptomyces sp. K04-0144, and the structure was elucidated by various NMR experiments. Nosokophic acid was found to be 3-phosphoglycosyl-2-sesquiterpenyl dihydroxypropionic acid, a predicted biosynthetic intermediate of nosokomycin-related moenomycins. The compound showed no activity against MRSA, but potentiated imipenem activity against MRSA by 512-fold.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nobuhiro Koyama, Yuriko Tokura, Yoko Takahashi, Hiroshi Tomoda,