Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369414 | Bioorganic & Medicinal Chemistry Letters | 2016 | 4 Pages |
Abstract
Piperazic acid, a non-proteinogenic amino acid, found in complex secondary metabolites and peptide natural substances, has shown down regulation of Gli1 expression in Hedgehog signaling pathway in cell based assays. Further structure activity relationship study indicated that amide derivatives of piperazic acid are more potent than piperazic acid itself, with little to no toxicity. However, other cellular components involved in the pathway were not affected. To the best of our knowledge, this is the first report on the inhibitory property of piperazic acid in this pathway. Hence, this molecule could serve as a useful tool for studying Hedgehog signaling.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Harleen Khatra, Jayanta Kundu, Pragya Paramita Khan, Indranil Duttagupta, Sankha Pattanayak, Surajit Sinha,