| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369453 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
N-(rhodamine B)-deoxylactam-5-amino-1-pentanol (dRB-APOH) was designed and prepared as the chromo-fluorogenic sensor for detection of a nerve agent simulant via analyte triggered tandem phosphorylation and opening of the intramolecular deoxylactam. The successful detection of diethyl chlorophosphate suggests the utility of rhodamine-deoxylactams as the chromo-fluorogenic signal reporting platform for design of sensors targeting reactive chemical species via various chemistries.
Graphical abstractN-(rhodamine B)-deoxylactam-5-amino-1-pentanol (dRB-APOH) was designed and prepared as the chromogenic and fluorogenic chemodosimerter for detection of a nerve agent simulant via analyte triggered tandem phosphorylation and opening of the intramolecualr deoxylactam.Figure optionsDownload full-size imageDownload as PowerPoint slide
