| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369465 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
In this letter, a high-throughput virtual screening was accomplished to identify potent inhibitors against AI-2 quorum sensing on the basis of Vibrio harveyi LuxPQ crystal structure. Seven compounds were found to inhibit AI-2 quorum sensing with IC50 values in the micromolar range, and presented low cytotoxicity or no cytotoxicity in V. harveyi.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Peng Zhu, Hanjing Peng, Nanting Ni, Binghe Wang, Minyong Li,