| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369472 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
1H-pyrrolo[2,3-c]pyridine-7-carboxamides constitute a new series of allosteric mGluR5 antagonists. Variation of the substituents attached to the heterocyclic scaffold allowed to improve the physico-chemical parameters for optimization of the aqueous solubility while retaining high in vitro potency.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
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Authors
Manuel Koller, David A. Carcache, David Orain, Peter Ertl, Dirk Behnke, Sandrine Desrayaud, Grit Laue, Ivo Vranesic,