| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369478 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
(±)-7,8-Dihydroxy-3-methyl-isochromanone-4 [(±)-XJP] is a natural antihypertensive product contained in banana (Musa sapientum L.) peel. (−)-XJP and (+)-XJP were first obtained by chiral resolution, meanwhile circular dichroism (CD) calculations and chiral synthesis were employed to investigate the absolute configuration. The results indicated that the absolute configuration of (+)-XJP is S-configured and the absolute configuration of (−)-XJP is R-configured. Furthermore, the evaluation of antihypertensive effects in vivo proved that R-(−)-XJP was more potent than S-(+)-XJP and [(±)-XJP].
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Renren Bai, Jie Liu, Yao Zhu, Xue Yang, Chen Yang, Lingyi Kong, Xiaobing Wang, Hengyuan Zhang, Hequan Yao, Mingqin Shen, Xiaoming Wu, Jinyi Xu,