| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369481 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
A novel series of diphenylpyridylethanamine-based inhibitors of cholesteryl ester transfer protein is described. Optimization of the urea moiety, particularly by incorporation of fluorine, is explored to balance in vitro metabolic stability with CETP potency in the whole plasma assay.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Michael M. Miller, Yalei Liu, Ji Jiang, James A. Johnson, Muthoni Kamau, David S. Nirschl, Yufeng Wang, Lalgudi Harikrishnan, David S. Taylor, Alice Ye A. Chen, Xiaohong Yin, Ramakrishna Seethala, Tara L. Peterson, Tatyana Zvyaga, Jun Zhang,