Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369497 | Bioorganic & Medicinal Chemistry Letters | 2016 | 5 Pages |
Abstract
The metabotropic glutamate receptors (mGlu receptors) have emerged as attractive targets for number of neurological and psychiatric disorders. Recently, mGluR5 negative allosteric modulators (NAMs) have gained considerable attention in pharmacological research. Comparative molecular field analysis (CoMFA) was performed on 73 analogs of aryl ether which were reported as mGluR5 NAMs. The study produced a statistically significant model with high correlation coefficient and good predictive abilities.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Chelliah Selvam, Ramasamy Thilagavathi, Balasubramanian Narasimhan, Pradeep Kumar, Brian C. Jordan, Kasturi Ranganna,