| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369507 | Bioorganic & Medicinal Chemistry Letters | 2016 | 4 Pages |
Abstract
A group of small molecule thienochromenes inhibitors of Notum Pectinacetylesterase are described. We developed SAR on three series based on carbon, oxygen and sulfur replacement of the 5-position. In each series, highly potent Notum Pectinacetylesterase inhibitors were identified.
Graphical abstractA group of small molecule thienochromenes inhibitors of Notum Pectinacetylesterase are described. We developed SAR on three series based on carbon, oxygen and sulfur replacement of the 5-position. In each series, highly potent Notum Pectinacetylesterase inhibitors were identified.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
![4H-Thieno[3,2-c]chromene based inhibitors of Notum Pectinacetylesterase](/preview/png/1369507.png "First Page Preview: 4H-Thieno[3,2-c]chromene based inhibitors of Notum Pectinacetylesterase")
Authors
Qiang Han, Praveen K. Pabba, Joseph Barbosa, Ross Mabon, Jason P. Healy, Michael W. Gardyan, Kristen M. Terranova, Robert Brommage, Andrea Y. Thompson, James M. Schmidt, Alan G.E. Wilson, Xiaolian Xu, James E. Tarver Jr., Kenneth G. Carson,