| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369510 | Bioorganic & Medicinal Chemistry Letters | 2016 | 4 Pages |
Abstract
Several novel compounds have been identified that inhibit the replication of hepatitis C virus in a replicon assay with EC50 values as low as 0.6 μM. Lead compounds were modified to investigate the possible role that zinc binding may play in inhibitor efficacy. In addition, the structure–activity relationship was explored to increase inhibitor efficacy and possibly identify favorable interactions within the currently unknown inhibitor binding pocket. The rationale for inhibitor design and biological results are presented herein.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Daniel C. Talley, Leen Delang, Johan Neyts, Pieter Leyssen, Paul J. Smith,