| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369528 | Bioorganic & Medicinal Chemistry Letters | 2016 | 5 Pages |
Abstract
A series of oxazolidinone and indole derivatives were synthesized and evaluated as IL-6 signaling blockers by measuring the effects of these compounds on IL-6-induced luciferase expression in human hepatocarcinoma HepG2 cells transfected with p-STAT3-Luc. Among different compounds screened, compound 4d was emerged as the most potent IL-6 signaling blockers with IC50 value of 5.9 μM which was much better than (+)-Madindoline A (IC50 = 21 μM), a known inhibitor of IL-6.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Sarbjit Singh, Veeraswamy Gajulapati, Kondaji Gajulapati, Ja-Il Goo, Yeon-Hwa Park, Hwa Young Jung, Sung Yoon Lee, Jung Ho Choi, Young Kook Kim, Kyeong Lee, Tae-Hwe Heo, Yongseok Choi,