| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369551 | Bioorganic & Medicinal Chemistry Letters | 2014 | 4 Pages |
Abstract
A water soluble β-1,3-glucan schizophyllan (SPG) can be recognized by an immunocyte receptor called dectin-1. When we introduced naphthalene into the side chain of SPG (nSPG), it formed nanogel by physical cross-link and gained capability to ingest hydrophobic compounds such as doxorubicin. Our in vitro assay revealed that this nanogel can be used as specific delivery of anti-cancer drugs to immunocytes.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Kazuya Maeda, Shinichi Mochizuki, Yusuke Sanada, Kazuo Sakurai,