| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369556 | Bioorganic & Medicinal Chemistry Letters | 2014 | 5 Pages |
A series of multisubstituted indole–acrylonitrile hybrids were designed, synthesized and evaluated for their potential cytotoxic activities. The bio-evaluation results indicated that some of the target compounds (such as 3a, 3f, 3k, 3n) exhibited good to moderate cytotoxic effect on HepG2, BCG-823, BEL-7402, and HL-7702 cell lines. Especially, the compounds 3a and 3k also exhibited high cytotoxic activities (3a, 19.38 ± 3.38 μM; 3k, 15.43 ± 3.54 μM) against the BEL-7402 cell line resistant to Taxol (>25 μM) and 5-FU (>500 μM), which might be developed as novel lead scaffold for potential anticancer agents.
Graphical abstractA series of multisubstituted indole–acrylonitrile hybrids were designed, synthesized and evaluated for their cytotoxic activity.Figure optionsDownload full-size imageDownload as PowerPoint slide
