Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369591 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
Malaria is a devastating world health problem. Using a compound library screening approach, we identified a novel series of disubstituted benzamide compounds with significant activity against malaria strains 3D7 and K1. These compounds represent a new antimalarial molecular scaffold exemplified by compound 1, which demonstrated EC50 values of 60 and 430 nM against strains 3D7 and K1, respectively. Herein we report our findings on the efficient synthesis, structure–activity relationships, and biological activity of this new class of antimalarial agents.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Katsuhiko Mitachi, Yandira G. Salinas, Michele Connelly, Nicholas Jensen, Taotao Ling, Fatima Rivas,