Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369594 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
The selectivity for 5-HT1A versus D4 receptors is significantly increased when the basic side chain of WAY-100635 is replaced by a 4-phenylpiperazine (3e) or a 4-phenyl-1,2,3,6-tetrahydropyridine moiety (3i). The 4-phenyl-1,2,3,6-tetrahydropyridine compounds (3i–l) have a higher affinity for 5-HT1A receptors than do the corresponding unsubstituted phenylpiperazine analogues (3e–h). Compounds 3e and 3i appear to be selective for 5-HT1A receptors over other relevant receptors and still behave as neutral antagonists.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Floriane Mangin, Sébastien Dilly, Benoît Joly, Jacqueline Scuvée-Moreau, Jon Evans, Vincent Setola, Bryan L. Roth, Jean-François Liégeois,