| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369599 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
Structural factors behind erm macrolide resistance were studied through synthesis of new macrolide derivates possessing truncated desosamine sugar moieties and subsequent determination of their antibacterial activity. Synthesized compounds with 2′-deoxy and 3′-desmethyl desosamine rings demonstrated decreased antibacterial activity on the native Staphylococcus aureus strain and were inactive against constitutively resistance S. aureus. The obtained results indicate that steric repulsion between the dimethylated A2058 and desosamine ring cannot be considered as a primary reason for erm-resistance.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Nicolas LeTourneau, Pavan Vimal, Dorota Klepacki, Alexander Mankin, Artem Melman,