| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369603 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
Novel substituted benzylidene-1,3-thiazolidine-2,4-diones (TZDs) have been identified as potent and highly selective inhibitors of the PIM kinases. The synthesis and SAR of these compounds are described, along with X-ray crystallographic, anti-proliferative, and selectivity data.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Les A. Dakin, Michael H. Block, Huawei Chen, Erin Code, James E. Dowling, Xiaomei Feng, Andrew D. Ferguson, Isabelle Green, Alexander W. Hird, Tina Howard, Erika K. Keeton, Michelle L. Lamb, Paul D. Lyne, Hannah Pollard, Jon Read, Allan J. Wu, Tao Zhang,