Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369615 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
Hit-to-lead evolution of 2-(2-((2-(4-chlorophenoxy)ethyl)thio)-1H-benzo[d]imidazol-1-yl)acetic acid (1), discovered in a high-throughput screening campaign as a novel chemotype of CRTh2 receptor antagonist, is presented. SAR development as well as in vitro and in vivo DMPK properties of selected representatives of substituted 2-(2-(benzylthio)-1H-benzo[d]imidazol-1-yl)acetic acids are discussed.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Julien Pothier, Markus A. Riederer, Oliver Peter, Xavier Leroy, Anja Valdenaire, Carmela Gnerre, Heinz Fretz,