Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369626 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
GSK189254 and its corresponding precursor GSK185071B were synthesized from 3-methoxyphenylacetic acid with 6-chloropyridine-3-carbolic acid or 6-chloronicotinamide in 8 and 7 steps with either 6% or 7% and either 14% or 16% yield, respectively. [11C]GSK189254 was prepared from GSK185071B with [11C]CH3OTf through N-[11C]methylation and isolated by HPLC combined with solid-phase extraction (SPE) in 50–60% radiochemical yield based on [11C]CO2 and decay corrected to end of bombardment (EOB), with 370–740 GBq/μmol specific activity at EOB.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Min Wang, Mingzhang Gao, Brandon L. Steele, Barbara E. Glick-Wilson, Clive Brown-Proctor, Anantha Shekhar, Gary D. Hutchins, Qi-Huang Zheng,