| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369637 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
A novel convergent method for the synthesis of α-acyl-γ-hydroxylactams utilizing the aldol reaction of N-Boc-protected γ-methoxylactams was developed. As the first application of this method for the synthesis of biologically active natural products, the total synthesis of platelet aggregation inhibitors PI-090 and PI-091 were also investigated and successfully achieved.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hiromi Uchiro, Nobuhiro Shionozaki, Yu Kobayakawa, Hiroko Nakagawa, Kimiko Makino,