Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369647 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
The pathogenesis of rheumatoid arthritis is mainly driven by NF-κB-mediated production of cytokines, such as TNF-α. We report herein that the orally available imidazoline-based NF-κB inhibitor, TCH-013, was found to significantly reduce TNF-α signaling and attenuate collagen antibody induced arthritis in BALB/c mice.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Theresa A. Lansdell, Sandra O’Reilly, Tracey Woolliscroft, Lauren M. Azevedo, Daljinder K. Kahlon, Stacy Hovde, J. Justin McCormick, R. William Henry, Joseph A. Cornicelli, Jetze J. Tepe,