| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369654 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
Haloenol pyran-2-ones and morpholin-2-ones were synthesized and evaluated as inhibitors of cell growth in two different prostate human cancer cell lines (PC-3 and LNCaP). Analogs derived from l- and d-phenylglycine were found to be the most effective antagonists of LNCaP and PC-3 cell growth. Additional studies reveal that the inhibitors induced G2/M arrest and the (S)-enantiomer of the phenylglycine-based derivatives was a more potent inhibitor of cytosolic iPLA2β.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Jason N. Mock, John P. Taliaferro, Xiao Lu, Sravan Kumar Patel, Brian S. Cummings, Timothy E. Long,