| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369656 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
Judicious modifications to the structure of the previously reported HCV NS5A inhibitor 1, resulted in more potent anti-HCV compounds with similar and in some cases improved toxicity profiles. The synthesis of 19 new NS5A inhibitors is reported along with their ability to block HCV replication in an HCV 1b replicon system. For the most potent compounds chemical stability, stability in liver microsomes and inhibition of relevant CYP450 enzymes is also presented.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Hongwang Zhang, Longhu Zhou, Franck Amblard, Junxing Shi, Drew R. Bobeck, Sijia Tao, Tamara R. McBrayer, Phillip M. Tharnish, Tony Whitaker, Steven J. Coats, Raymond F. Schinazi,