Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369661 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
In an attempt to search for many target compounds with excellent activities, a series of vinyl ether-containing azole derivatives were designed, synthesized, and evaluated as antifungal agents. Results of preliminary antifungal tests against Trichophyton rubrum in vitro indicated that most of the synthesized compounds showed excellent activities. In comparison with fluconazole, itraconazole, voriconazole, omoconazole and amphotericin B, several compounds (such as 7d, 7g and 7h) exhibited more potent inhibitory activities, suggesting that they were promising leads for the development of novel antifungal agents.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Lulu Wang, Wenge Yang, Kai Wang, Jing Zhu, Fei Shen, Yonghong Hu,