Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369705 | Bioorganic & Medicinal Chemistry Letters | 2016 | 7 Pages |
Abstract
2-Arachidonoylglycerol (2-AG) is an endocannabinoid that activates the cannabinoid receptors type 1 and 2. It also serves as an important lipid precursor for the eicosanoid signaling pathway. Consequently, 2-AG is involved in many physiological functions, including anxiety, food intake, inflammation, memory, pain sensation and neurotransmission. Diacylglycerol lipases (DAGLs) are the main biosynthetic enzymes for 2-AG and their role in several pathophysiological conditions is currently under investigation. In this Digest we review all DAGL inhibitors reported to date and their effects in preclinical models of neurodegeneration and metabolic disorders.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Freek J. Janssen, Mario van der Stelt,