Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369707 | Bioorganic & Medicinal Chemistry Letters | 2016 | 4 Pages |
Abstract
Previously we identified the first retinoid X receptor-alpha (RXRα) modulators that regulate the RXRα biological function via binding to the coregulator-binding site. Here we report the characterization of the interactions between the hit molecule and RXRα through computational modeling, mutagenesis, SAR and biological evaluation. In addition, we reported studies of additional new compounds and identified a molecule that mediated the NF-κB pathway by inhibiting the TNFα-induced IκBα degradation and p65 nuclear translocation.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Dingyu Xu, Shangjie Guo, Ziwen Chen, Yuzhou Bao, Fengyu Huang, Dan Xu, Xindao Zhang, Zhiping Zeng, Hu Zhou, Xiaokun Zhang, Ying Su,