Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369715 | Bioorganic & Medicinal Chemistry Letters | 2016 | 6 Pages |
Abstract
A facile and rapid access to resveratrol derivatives has been achieved based on palladium-catalyzed oxidative Heck reaction of aryl boronic acids with styrenes followed by demethylation in moderate to good yields. A series of resveratrol derivatives with various functional groups has been synthesized easily. The radioprotective activity of synthesized compounds has also been evaluated using rat thymocytes. The results revealed that some resveratrol derivatives efficiently protected the thymocytes from radiation-induced apoptosis.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Saori Uzura, Emiko Sekine-Suzuki, Ikuo Nakanishi, Motohiro Sonoda, Shinji Tanimori,