| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369716 | Bioorganic & Medicinal Chemistry Letters | 2016 | 4 Pages |
Abstract
A small series of N-glycosylsulfonamides incorporating the phenol moiety has been prepared by Ferrier sulfonamidoglycosylation of d-glycals. N-Glycosides were tested for the inhibition of four isoforms of carbonic anhydrase. In this study, all compounds showed good inhibitory activity against hCA I and II, with selectivity against the cytosolic hCA II versus the tumor associated isozymes. These results confirm that attaching carbohydrate moieties to CA phenol pharmacophore improves and enhances its inhibitory activity.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Leonardo E. Riafrecha, Silvia Bua, Claudiu T. Supuran, Pedro A. Colinas,