| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369718 | Bioorganic & Medicinal Chemistry Letters | 2016 | 8 Pages |
Abstract
Numerous potent P2X3 antagonists have been discovered and the therapeutic potential of P2X3 antagonism already comprises proof-of-concept data obtained in clinical trials with the most advanced compound. We have lately reported the discovery and optimization of thia-triaza-tricycle compounds with potent P2X3 antagonistic properties. This Letter describes the SAR of a back-up series containing a 4-oxo-quinazoline central ring. The discovery of the highly potent compounds 51 is presented.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Gábor Szántó, Attila Makó, István Vágó, Tamás Hergert, Imre Bata, Bence Farkas, Sándor Kolok, Mónika Vastag,