| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369719 | Bioorganic & Medicinal Chemistry Letters | 2016 | 5 Pages |
Abstract
Five new compounds, named ancistronaphtosides A and B (1 and 2), anciscochine (3), anciscochine 6-O-β-d-glucopyranoside (4), and 4′-methoxy-5-epi-ancistecrorine A1 (5), together with tortoside A (6) and 4-hydroxy-2-methoxyphenyl-6-O-syringoyl-β-d-glucopyranoside (7) were isolated from the methanolic extract of Ancistrocladus cochinchinensis. Their chemical structures were established using HR-ESI-MS, NMR spectroscopic, and chiroptical methods. Compound 5 significantly exhibited anti-proliferation against HL-60, LU-1, and SK-MEL-2 cells with IC50 values of 5.0 ± 1.2, 6.5 ± 1.6, and 6.8 ± 2.0 μg/mL, respectively.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Le Quynh Lien, Tran My Linh, Vu Huong Giang, Nguyen Chi Mai, Nguyen Xuan Nhiem, Bui Huu Tai, Nguyen Thi Cuc, Hoang Le Tuan Anh, Ninh Khac Ban, Chau Van Minh, Phan Van Kiem,