| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369743 | Bioorganic & Medicinal Chemistry Letters | 2016 | 10 Pages |
Abstract
We describe several novel curcumin analogues that possess both anti-inflammatory antioxidant properties and thrombolytic activities. The therapeutic efficacy of these curcumin analogues was verified in a mouse ear edema model, a rat arterial thrombosis assay, a free radical scavenging assay performed in PC12 cells, and in both in vitro and in vivo ischemia/reperfusion models. Our findings suggest that their protective effects partially reside in maintenance of optimal mitochondrial function.
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Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Wei Bi, Yue Bi, Xiang Gao, Xin Yan, Yanrong Zhang, Jackie Harris, Thomas D. Legalley, K. Michael Gibson, Lanrong Bi,