Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369745 | Bioorganic & Medicinal Chemistry Letters | 2016 | 4 Pages |
Abstract
The use of existing antibiotics in the form of prodrug followed by activation using enzymes of pathogenic origin could be a useful approach for antimicrobial therapy. To investigate this idea, a common antibiotic, sulfamethoxazole has been redesigned in the form of a prodrug by simple functional group replacement. Upon reductive activation by a type I nitroreductase from a pathogen, the drug displayed enhanced antimicrobial capacity. This strategy could improve the efficacy and selectively of antibiotics and reduce the incidence of resistance.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Ayhan Çelik, Gülden Yetiş, Mehmet Ay, Tuğba Güngör,