| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369748 | Bioorganic & Medicinal Chemistry Letters | 2016 | 4 Pages |
Abstract
In a search for novel small molecule calcium-sensing receptor (CaSR) antagonists as oral bone anabolic agents, we discovered dihydrobenzofuran cyclopropane carboxylic acid derivatives, such as 12f (IC50 = 27.6 nM), are highly potent calcium-sensing receptor antagonists. Studies in rats established that compound 12f stimulates parathyroid hormone (PTH) release in a fast-acting, pulsatile manner.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Gui-Bai Liang, Changyou Zhou, Xianghong Huo, Hank Wang, Xuelin Yang, Shaoqiang Huang, Haisheng Wang, Hilary Wilkinson, Lusong Luo, Wei Tang, David Sutton, Hong Li, Dennis Zaller, Peter T. Meinke,