| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369770 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
Ianthellamide A (1), a novel octopamine derivative, was isolated from the Australian marine sponge Ianthella quadrangulata. Compound 1 selectively inhibited the activity of kynurenine 3-hydroxylase with an IC50 value of 1.5 μM. It also significantly increased the level of endogenous kynurenic acid in rat brain and hence has the potential as a neuroprotective agent in the treatment of neurodegenerative disorders.
Graphical abstractFigure optionsDownload full-size imageDownload as PowerPoint slide
Keywords
Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Yunjiang Feng, Bruce F. Bowden, Vimal Kapoor,