| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369781 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
A regioselective route to novel mono triazolyl substituted quinolines has been developed via copper-catalyzed azide–alkyne cycloaddition (CuAAC) of 2,4-diazidoquinoline with terminal alkynes in DMF. The reaction provided bis triazolyl substituted quinolines when performed in water in the presence of Et3N. A number of the compounds synthesized showed promising anti-proliferative properties when tested in vitro especially against breast cancer cells.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Amarender Reddy Ellanki, Aminul Islam, Veera Swamy Rama, Ranga Prasad Pulipati, D. Rambabu, G. Rama Krishna, C. Malla Reddy, K. Mukkanti, G.R. Vanaja, Arunasree M. Kalle, K. Shiva Kumar, Manojit Pal,