| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369784 | Bioorganic & Medicinal Chemistry Letters | 2012 | 7 Pages |
Fifty-seven derivatives of glycyrrhetinic acid (GA) were synthesized, and their anti-hepatitis B virus (HBV) activity was evaluated in HepG 2.2.15 cells. Among them, sixteen compounds showed greater anti-HBV activity than GA, especially, compounds 29, 32, 35, 41 exhibited significantly inhibitory activities against HBV DNA replication with IC50 values of 5.71, 5.36, 8.90 and 9.08 μM, respectively. The structure–activity relationships (SARs) of GA derivatives were discussed for exploring novel anti-HBV agents.
Graphical abstractFifty-seven derivatives of glycyrrhetinic acid (GA) were synthesized, and their anti-hepatitis B virus (HBV) activity was evaluated in HepG 2.2.15 cells. Among them, sixteen compounds showed greater anti-HBV activity than GA, especially, compounds 29, 32, 35, 41 exhibited significantly inhibitory activities against HBV DNA replication with IC50 values of 5.71, 5.36, 8.90 and 9.08 μM, respectively. The structure–activity relationships (SARs) of GA derivatives had been discussed.Figure optionsDownload full-size imageDownload as PowerPoint slide
