Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369789 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
Disrupting the interaction between the p53 tumor suppressor and its regulator MDM2 is a promising therapeutic strategy in anticancer drug research. In our search for non peptide inhibitors of this protein–protein interaction, we have devised a ligand design concept exploiting the central position of Val 93 in the p53 binding pocket of MDM2. The design of molecules based on this concept has allowed us to rapidly identify compounds having a 3-imidazolyl indole core structure as the first representatives of a new class of potent inhibitors of the p53–MDM2 interaction.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Pascal Furet, Patrick Chène, Alain De Pover, Thérèse Stachyra Valat, Joanna Hergovich Lisztwan, Joerg Kallen, Keiichi Masuya,