| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369792 | Bioorganic & Medicinal Chemistry Letters | 2012 | 6 Pages |
Abstract
Pyrrolidine based peptidomimetics are reported as potent and selective DPP-IV inhibitors for the treatment of T2DM. Compounds 16c and 16d showed excellent in vitro potency and selectivity towards DPP-IV and the lead compound 16c showed sustained antihyperglycemic effects, along with improved pharmacokinetic profile.
Graphical abstractPeptidomimetic based cyanopyrrolidine derivatives are reported as potent and selective DPP-IV inhibitors. The lead compound (16c) showed long acting antihyperglycemic effects, along with improved pharmacokinetic profile.Figure optionsDownload full-size imageDownload as PowerPoint slide
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Authors
Pradip Jadav, Rajesh Bahekar, Shailesh R. Shah, Dipam Patel, Amit Joharapurkar, Samadhan Kshirsagar, Mukul Jain, Mubeen Shaikh, Kalapatapu V.V.M. Sairam,