| Article ID | Journal | Published Year | Pages | File Type |
|---|---|---|---|---|
| 1369796 | Bioorganic & Medicinal Chemistry Letters | 2012 | 5 Pages |
Abstract
A series of thirty-three thymol, p-cymene-3-carboxylic acid, and 3-amino-p-cymene derivatives was synthesized and tested on TRPA1, TRPM8, and TRPV3 channels. Most of them acted as strong modulators of TRPA1, TRPM8, and TRPV3 channels with EC50 and/or IC50 values distinctly lower than those of thymol and related monoterpenoids. Some of the compounds examined, that is, 3c, 4e, f, 6b, and 8b exhibited an appreciable subtype-selectivity.
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Related Topics
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Chemistry
Organic Chemistry
Authors
Giorgio Ortar, Ludovica Morera, Aniello Schiano Moriello, Enrico Morera, Marianna Nalli, Vincenzo Di Marzo, Luciano De Petrocellis,