Article ID | Journal | Published Year | Pages | File Type |
---|---|---|---|---|
1369799 | Bioorganic & Medicinal Chemistry Letters | 2012 | 4 Pages |
Abstract
Small molecule screening identified 5-nitro-7-((4-phenylpiperazine-1-yl-)methyl)quinolin-8-ol INP1750 as a putative inhibitor of type III secretion (T3S) in the Gram-negative pathogen Yersinia pseudotuberculosis. In this study we report structure–activity relationships for inhibition of T3S and show that the most potent compounds target both the extracellular bacterium Y. pseudotuberculosis and the intracellular pathogen Chlamydia trachomatis in cell-based infection models.
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Related Topics
Physical Sciences and Engineering
Chemistry
Organic Chemistry
Authors
Per-Anders Enquist, Åsa Gylfe, Ulrik Hägglund, Pia Lindström, Henrik Norberg-Scherman, Charlotta Sundin, Mikael Elofsson,